منابع مشابه
AR-V7 Expression Predicts Prostate Cancer Outcomes
Radical prostatectomy (RP) specimens with unfavorable pathol‐ ogy increased over nine years, but the reasons remain unclear, according to a study reported at the American Urological Asso‐ cia on (AUA) 2016 Annual Mee ng. Results were reported by Katherine Rotker, MD, of Brown University in Providence, RI. Following US Preven ve Health Services Task Force (USPSTF) 2009 and 2012 recommenda ons ag...
متن کاملAndrogen receptor splice variant V7 (AR-V7) in circulating tumor cells: a coming of age for AR splice variants?
Prostate cancer continues to be the most common non-cutaneous malignancy afflicting men in developed countries [1]. Although surgery or radiotherapy for the primary disease appears be curative at the time of initial treatment, upward of 25% of men will have metastatic or residual disease (ACS Facts and Figures 2015). Since the advent of prostate-specific antigen assays, the recurrence of the ca...
متن کاملDevelopment of AR-V7 as a putative treatment selection marker for metastatic castration-resistant prostate cancer
Prostate cancer cells demonstrate a remarkable "addiction" to androgen receptor (AR) signaling in all stages of disease progression. As such, suppression of AR signaling remains the therapeutic goal in systemic treatment of prostate cancer. A number of molecular alterations arise in patients treated with AR-directed therapies. These molecular alterations may indicate the emergence of treatment ...
متن کاملDroplet Digital PCR Based Androgen Receptor Variant 7 (AR-V7) Detection from Prostate Cancer Patient Blood Biopsies
Androgen receptor splice variant V7 (AR-V7) was recently identified as a valuable predictive biomarker in metastatic castrate-resistant prostate cancer. Here, we report a new, sensitive and accurate screen for AR-V7 mRNA expression directly from circulating tumor cells (CTCs): We combined EpCAM-based immunomagnetic CTC isolation using the IsoFlux microfluidic platform with droplet digital polym...
متن کاملHOJ-2003 v7
Wolfgang Fitz, MD Brigham and Women’s Hospital Department of Orthopaedic Surgery 75 Francis St. Boston, MA 02115 Office: 617-732-5401 Email: [email protected] INTRODUCTION Infection is a devastating complication of total knee arthroplasty, affecting up to 2% of primary knee arthroplasties and up to 5.6% of revision knee arthroplasties. [1] Two-staged reconstruction --with thorough debridement ...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2018
ISSN: 1759-4774,1759-4782
DOI: 10.1038/s41571-018-0072-5